Ectasia sanders biography of abraham

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Abstract

Background

Cardiomegaly caused by left ventricular hypertrophy is a risk factor for development of congestive heart failure, classically associated with decreased systolic and/or diastolic ventricular function. Less attention has been given to the phenotype of left ventricular hypertrophy with enhanced ventricular function and increased cardiac output, which is potentially associated with high‐output heart failure. Lack of recognition may pose diagnostic ambiguity and management complexities.

Methods and Results

We sought to systematically characterize high‐output cardiac hypertrophy in subjects with Cantu syndrome (CS), caused by gain‐of‐function variants in ABCC9, which encodes cardiovascular K_ATP (ATP‐sensitive potassium) channel subunits. We studied the cardiovascular phenotype longitudinally in 31 subjects with CS with confirmed ABCC9 variants (median [interquartile range] age 8 years [3–32 years], body mass index 19.9 [16.5–22.9], 16 male subjects). Subjects with CS presented with significant left ventricular hypertrophy (left ventricular mass index 86.7 [57.7–103.0] g/m² in CS, n=30; 26.6 [24.1–32.8] g/m² in controls, n=17; P<0.0001) and low blood pressure (systolic 94.5 [90–103] mm Hg in CS, n=17; 109 [98–115] mm Hg in controls, n=17; P=0.

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Oncology
Letters

Introduction

Breast cancer is the most common malignant tumor among women, and its incidence has remained high for many years (1), accounting for 8–12% of the malignant tumors in the whole body (2). According to the data, there are more than one million cases of breast cancer diagnosed globally every year, and approximately 410,000 deaths (3). Breast cancer is more common in Europe, North America and other developed cities, among which the United States has the highest incidence in the world (4). According to Turner et al (5), in the next 50 years, the incidence of breast cancer will exceed 50%, becoming the second most common malignant tumor after gastric cancer. Furthermore, as early breast cancer has no obvious characteristics, it is often ignored by patients, making them miss the best treatment period, leading to high mortality. The fatality of breast cancer in situ is not high, but once the cancer cells fall off, free cancer cells can be transferred to any place through blood circulation and lymph circulation, and the threat of breast cancer is greatly increased (6). Therefore, ‘early detection and early treatment’ is advocated for the occurrence of breast cancer in clinical practice, and timely intervention treatment is conducted to ensure the health

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