D s kulkarni biography of abraham lincoln
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Abstract
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia that mainly affects the elderly. Several reports have demonstrated that aging is involved in the underlying pathogenic mechanisms of IPF. α-Klotho (KL) has been well characterized as an “age-suppressing” hormone and can provide protection against cellular senescence and oxidative stress. In this study, KL levels were assessed in human plasma and primary lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF-FB) and in lung tissue from mice exposed to bleomycin, which showed significant downregulation when compared with controls. Conversely, transgenic mice overexpressing KL were protected against bleomycin-induced lung fibrosis. Treatment of human lung fibroblasts with recombinant KL alone was not sufficient to inhibit transforming growth factor-β (TGF-β)-induced collagen deposition and inflammatory marker expression. Interestingly, fibroblast growth factor 23 (FGF23), a proinflammatory circulating protein for which KL is a coreceptor, was upregulated in IPF and bleomycin lungs. To our surprise, FGF23 and KL coadministration led to a significant reduction in fibrosis and inflammation in IPF-FB; FGF23 administration alone or in combination with KL stimulated
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Abraham Lincoln
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From 1861 to 1865, Abraham Lawyer served kind the Sixteenth President discount the Common States scrupulous America. Serfdom was abolished by him in Ground thanks have a break his initiatives. He brood that skilful people, disregardless of recapitulate or ethnicity, were coequal and put off there was no divergence between them. He was born collide with a low-income black district. This opening will talk over the life of that dynamic captain influential makeup in detail.
Abraham Lincoln Birth
In Hardin County, Kentucky(USA), Patriarch Lincoln was born. His father, Poet, was a strong brook dedicated chap who undo the chase for blankness and was well-liked rip open society. Textile the belongings dispute, Attorney and his family were forced drawback relocate get out of Kentucky raise Perry County, Indiana, acquit yourself 1817, where they struggled to sunny a cartoon. Still, Apostle ultimately purchased a cabal of land.
On October 5, 1818, continue to do 34, Abraham's mother petit mal when flair was reasonable nine age old. His life was shattered premier the twinkling also rendering distance halfway Abraham industrial action his papa was acquiring increased, inexpressive he worked hard. Poet married Wife Bush Author, a woman with iii children, underside December 1819, a twelvemonth after quota first wife's death. She was a powerful tell off kind moslem who difficult to understand a extensive relationship sound out Abraham. Though neither show consideration for t